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A Nonhuman Primate Toxicology and Immunogenicity Study Evaluating Aerosol Delivery of AERAS-402/Ad35 Vaccine

Hokey, D.A., Wachholder, R., Darrah, P.A., Bolton, D.L.,  Barouch, D.H., Hill, K.,
Dheenadhayalan, V., Schwander, S., Godin, C.S.,  Douoguih, M., Pau, M.G., Seder,R.A., Roederer, M., Sadoff, J.C., and Sizemore, D. 2014. A Nonhuman PrimateToxicology and Immunogenicity Study Evaluating Aerosol Delivery of AERAS-402/Ad35 Vaccine:  Evidence for Transient T Cell Responses in Peripheral Blood andRobust Sustained Responses in the Lungs. Human Vaccines and Immunotherapeutics,
10.4161/hv.29108.

Featured Publication
Reproductive and Developmental Toxicity Testing

Examination of the Extended One-Generation Reproductive Toxicity Study Guideline
Authors:Shakil A Saghir, Ph.D. and Michael A Dorato, Ph.D.

This whitepaper discusses ways to make the EOGRTS guideline easier to follow; suggesting procedures to select relevant doses, and monitor the systemic exposure at different life stages for better interpretation of the data.