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Developmental Toxicology Validation Program Evaluating the Teratogenic Effects Produced when 6-Aminonicotinamide or Acetylsalicylic Acid are Administered to Pregnant New Zealand White Rabbits or Sprague Dawley Rats, Respectively on Specific Gestation Days

Known teratogens have been utilized to generate fetal abnormalities to support developmental toxicology training programs. These technical validation studies investigated the teratogenicity of 6-aminonicotinamide (6-AN) in New Zealand White Rabbits and acetylsalicylic acid (ASA) in Sprague Dawley rats. 

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Reproductive and Developmental Toxicity Testing

Examination of the Extended One-Generation Reproductive Toxicity Study Guideline
Authors:Shakil A Saghir, Ph.D. and Michael A Dorato, Ph.D.

This whitepaper discusses ways to make the EOGRTS guideline easier to follow; suggesting procedures to select relevant doses, and monitor the systemic exposure at different life stages for better interpretation of the data.