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Nonclinical Embryo-fetal Development Assessment of GLYX-13 (rapastinel), an NMDAR Novel Modulator in Rats and Rabbits

Wolfe, G.W., Atkinson, B.A., Houck, D., and Gidda, J.:  Nonclinical Embryo-fetal Development Assessment of GLYX-13 (rapastinel), an NMDAR Novel Modulator in Rats and Rabbits.  Presented at the 54th Annual Meeting of the Society of Toxicology, San Diego, CA March 25, 2015.

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Reproductive and Developmental Toxicity Testing

Examination of the Extended One-Generation Reproductive Toxicity Study Guideline
Authors:Shakil A Saghir, Ph.D. and Michael A Dorato, Ph.D.

This whitepaper discusses ways to make the EOGRTS guideline easier to follow; suggesting procedures to select relevant doses, and monitor the systemic exposure at different life stages for better interpretation of the data.