Developmental and Reproductive Toxicology

Smithers Avanza Toxicology Services evaluates reproduction and development for assessment of potential human reproductive risk. Each study is designed to meet the specifications of the appropriate scientific and regulatory guidance. Studies include Extended One Generation Reproductive Toxicity Study (EOGRTS).

 

For more information about our Developmental and Reproductive Toxicology studies, download our brochure, or contact Dr. Caitlin Murphy, Senior Toxicologist, at 240.364.6316 or Caitlin.Murphy@smithers.com.

Scope and Range of Services

The Smithers Avanza Toxicology Services team has extensive experience conducting GLP-compliant Developmental and Reproductive Toxicology studies that meet global regulatory test guidelines (ICH, FDA, EPA, OECD, EU, and MOHW) including:

  • Studies for preclinical development of large and small molecules
  • Routine and specialized routes of dose administration
  • Fertility (male and/or female)
  • Embryo-fetal development
  • Prenatal and postnatal development, including maternal function
  • Maternal antibody transfer
  • Combined 28-day/reproduction screening
  • Developmental neurotoxicology
  • Endocrine disruptor screening assays
  • Postnatal development assessment
    • Anogenital distance
    • Eye opening
    • Incisor eruption
    • Pinna unfolding
    • Preputial separation
    • Testicular descent
    • Vaginal opening
    • Functional Observation Battery

 

We have an expert team of industry professionals led by Dr. Caitlin Murphy, who specializes in developmental and reproductive biology and toxicology.

Scientific consultants

  • Dr. Stephen Harris is an internationally recognized expert in Developmental and Reproductive Toxicology
  • Dr. Mary Jeanne Kallman is an international industry expert in neurotoxicity and behavioral assessment

Recent investments in DART capabilities

  • Quality consultation provided by Drs. Kallman and Harris for all of our technical team and support staff
  • Expanding our reproductive historical control data base
  • State-of-the-art instruments
    • Sperm Motility and Density using Hamilton Thorne IVOS II
    • Automated Behavioral Assessment through Kinder Scientific Instruments
      • Avoidance Monitor II
      • Motor Monitor
      • Startle Monitor II