Vaccine Safety Testing

Smithers Avanza Toxicology Services has extensive experience with a wide variety of in vivo toxicology studies examining effects of vaccine candidates.

Vaccine safety testing is conducted in an AAALAC International accredited, Biosafety Level-2 laboratory.

Assessments include immune response and biodistribution of a variety of vaccine types in multiple species and routes of administration.

Vaccine Studies

  • General Toxicology/Safety
  • Immunogenicity
  • In Vivo Adjuvant Selection
  • Potency
  • Proof-of-Concept
  • Prime-Boost Design
  • Biodistribution and Integration

 Administration Routes

  • Intranasal
  • Pulmonary
  • Intravesicular
  • Intramuscular
  • Subcutaneous
  • Dermal (patch)
  • Intradermal

 Vaccine Experience

  • Vaccines Evaluated Include: Influenza, Measles, TB, ETEC, Anthrax, Norovirus, Ebola, HIV, Dengue, Plague, WNV, SARS, Malaria, Botulinum Toxin, several cancers
  • Clinical Pathology Analyses Including C-Reactive Protein
  • Histopathology Evaluation Including Sites of Administration
  • Biodistribution Using Sterilized Necropsy Techniques