Toxicology Services Team

Michael A. Dorato

  • Executive Vice President
  • Toxicology Services

Dr. Dorato has over 35 years of experience, as a researcher and global leader of safety and efficacy in the pharmaceutical and CRO industries. Prior to joining Smithers, he was the Vice-President and CSO, Global Discovery Services (Covance) and Executive Director, Toxicology (Eli Lilly and Co.). In these positions he led global organizations in safety and efficacy lead optimization, investigative and regulatory toxicology, discovery and late phase pathology, animal welfare, molecular and anatomical imaging, in vivo pharmacology, veterinary medicine and model development. Dr. Dorato has more than 100 scientific publications/presentations.

Shakil A. Saghir

  • Principal Toxicologist
  • Toxicology Services

Dr. Saghir has over 30 years of experience in the agrochemical and chemical industries. His professional experience includes toxicology roles at The Dow Chemical Company, Syngenta and consulting for agro- and industrial chemicals, consumer products, and pharmaceuticals. Dr. Saghir is a DABT and a European Registered Toxicologist, and has considerable experience with toxicokinetics, risk assessment and regulatory compliance. He has experience in registration and stewardship of products, as well as PK/TK and bioavailability data analysis/modeling. Dr. Saghir has over 340 publications/presentations/technical reports including book chapters and peer reviewed articles.

Steven Godin

  • Principal Toxicologist
  • Toxicology Services

Dr. Godin has over 30 years of experience in the CRO industry and pharmaceutical drug development, resulting in a diverse and unique combination of experience and leadership. Prior to joining Smithers Avanza Toxicology Services, he held scientific and leadership roles at Wright-Patterson Air Force Base, MPI Research, White Eagle Laboratories, and Cephalon. His areas of expertise include drug metabolism, biochemical toxicology, ocular and dermal toxicity, safety studies of oncology products, vaccine safety and biodistribution studies, reproductive toxicity studies in canines and felines, target animal safety studies of veterinary pharmaceuticals, juvenile toxicology studies, wound healing studies, and developing, implementing, and conducting novel testing protocols. He has also served as Principle Investigator on programs for the National Cancer Institute, the National Institute on Drug Abuse, and the National Institute of Allergy and Infectious Diseases. He is experienced in providing preclinical advice on scientific issues in drug development, has participated pre-IND meetings with the FDA, and was a member of project teams which resulted in successful filing of INDs and NDAs for the FDA. He has over 100 publications and abstract presentations in scientific journals and at conferences.

Caitlin J. Murphy

  • Senior Toxicologist
  • Toxicology Services

Dr. Murphy has 10 years of experience, as a researcher in developmental and reproductive toxicology. Prior to joining Smithers Avanza Toxicology, she was a Postdoctoral Fellow at the University of Texas at Austin in the Division of Pharmacology and Toxicology. She has extensive scientific knowledge in diverse disciplines including rodent toxicity, drug discovery toxicology, immunotoxicology, and reproductive and developmental toxicology. She specializes in rodent reproductive toxicology with previous experience including, but not limited to, fertility (male and female), prenatal and postnatal development, endocrine screening, and multigenerational studies. She has directed and designed numerous toxicology studies using animal and in vitro models to evaluate drug safety and environmental toxicants. Dr. Murphy has over 20 publications/presentations in scientific journals and/or conferences.

Carol S. Spicer

  • Senior Director, Compliance & Toxicology Services
  • Toxicology Services

Ms. Spicer has over 30 years of experience in the contract research industry. Her experience includes hands-on technical experience, management of operational and support functions, oversight of institutional training and IACUC administration. She has extensive background in SOP development, regulatory inspections, process improvements/corrective actions and operations based application of GLP best practices. Current areas of oversight include QAU, IACUC, Health and Safety, Archives, Metrology, and Shipping and Receiving.

Michael R. Brunty

  • Director, Operations
  • Toxicology Services

Mr. Brunty has over 17 years of experience in financial and technical aspects of non-clinical in vivo studies for toxicological assessment of small molecules, biologics and vaccines. Mr. Brunty has extensive experience in personnel management, project management and business development. Having completed Lean Six Sigma training at the Green Belt level, Mr. Brunty embraces the challenges of process improvement while maintaining a stringent standard of quality for all client deliverables.

Peggy Miller

  • Director, Quality Assurance
  • Toxicology Services

Ms. Miller has over 30 years’ experience in pre-clinical toxicology studies in support of regulatory submission. Ms Miller is experienced in monitoring, analyzing, reporting, auditing, and coordinating non-clinical toxicology research studies and has extensive management and supervisory experience within the coordinating/reporting aspects and Quality Assurance. Previous positions reveal increasing responsibilities that included non-clinical laboratory experience, knowledge of regulatory guidelines and regulations, project management, validation, Quality Assurance, and regulatory affairs.